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Báo cáo khoa học: " The role of mutations in core protein of hepatitis B virus in liver fibrosis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The role of mutations in core protein of hepatitis B virus in liver fibrosis | Virology Journal BioMed Central Research The role of mutations in core protein of hepatitis B virus in liver fibrosis Ashraf Mohamadkhani 1 2 Ferdous Rastgar Jazii1 Hossein Poustchi2 Omidreza Nouraein1 Shahsanam Abbasi1 Masoud Sotoudeh2 and Ghodratollah Montazeri2 Address National Institute of Genetic Engineering and Biotechnology Tehran Iran and 2Digestive Disease Research Centre Shariati Hospital Medical Science University of Tehran Tehran Iran Email Ashraf Mohamadkhani - ashraf@ams.ac.ir Ferdous Rastgar Jazii - Rastgar@nigeb.ac.ir Hossein Poustchi - poustchi@ams.ac.ir Omidreza Nouraein - omidreza@nigeb.ac.ir Shahsanam Abbasi - Abbasi@nigeb.ac.ir Masoud Sotoudeh - sotodeh@ams.ac.ir Ghodratollah Montazeri - montazer@ams.ac.ir Corresponding author Open Access Published 26 November 2009 Virology Journal 2009 6 209 doi 10.1186 I743-422X-6-209 Received 4 August 2009 Accepted 26 November 2009 This article is available from http www.virologyj.cOm content 6 1 209 2009 Mohamadkhani et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ The core protein of hepatitis B virus encompasses B- and T-cell immunodominant epitopes and subdivided into two domains the N-terminal and the functional C-terminal consisted phosphorylation sites. Mutations of the core gene may change the conformation of the core protein or cause alteration of important epitopes in the host immune response. In this study twenty nine men mean age 40 9 years old with chronic hepatitis B were recruited for direct sequencing of the core gene. Serum ALT and HBV DNA level were measured at the time of liver biopsy. The effects of core protein mutations on patients characteristics and .