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Báo cáo y học: "Antigenic presentation of heterologous epitopes engineered into the outer surface-exposed helix 4 loop region of human papillomavirus L1 capsomeres"

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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Antigenic presentation of heterologous epitopes engineered into the outer surface-exposed helix 4 loop region of human papillomavirus L1 capsomeres | Virology Journal BioMed Central Research Antigenic presentation of heterologous epitopes engineered into the outer surface-exposed helix 4 loop region of human papillomavirus L1 capsomeres Yoshihiko Murata 1 2 Paula M Lightfoote1 Robert C Rose1 3 and Edward E Walsh1 2 Open Access Address 1Division of Infectious Diseases Department of Medicine University of Rochester School of Medicine and Dentistry Rochester New York 14642 USA 2Infectious Diseases Unit Department of Medicine Rochester General Hospital Rochester New York 14621 USA and 3Department of Microbiology and Immunology University of Rochester School of Medicine and Dentistry Rochester New York 14642 USA Email Yoshihiko Murata - Yoshihiko_Murata@urmc.rochester.edu Paula M Lightfoote - Paula_Lightfoote@urmc.rochester.edu Robert C Rose - Robert_Rose@urmc.rochester.edu Edward E Walsh - Edward.Walsh@rochestergeneral.org Corresponding author Published 18 June 2009 Received 3 April 2009 Virology Journal 2009 6 81 doi 10.1186 1743-422X-6-81 Accepted 18 June 2009 This article is available from http www.virologyj.cOm content 6 1 81 2009 Murata et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Human papillomavirus HPV L1 capsid proteins can self-assemble into pentamers capsomeres that are immunogenic and can elicit neutralizing antibodies. Structural modelling of L1 inter-pentameric interactions predicts that helix 4 h4 of each of the five L1 monomers project laterally and outwards from the pentamer. We sought to utilize HPV L1 capsomeres as a vaccine platform by engineering heterologous epitopes within L1 derivatives deleted for h4 domain. Results We used baculovirus - .

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