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Báo cáo khoa học: "Isolation and characterization of a genotype 4 Hepatitis E virus strain from an infant in China"

Isolation and characterization of a genotype 4 Hepatitis E virus strain from an infant in China | Virology Journal BioMed Central Open Access Short report Isolation and characterization of a genotype 4 Hepatitis E virus strain from an infant in China Wen Zhang Shixing Yang Quan Shen Junfeng Liu Tongling Shan Fen Huang Huibo Ning Yanjun Kang Zhibiao Yang Li Cui Jianguo Zhu and Xiuguo Hua Address Zoonosis and Comparative Medicine Group School of Agriculture and Biology Shanghai JiaoTong University 800 Dongchuan Road Shanghai PR China Email Wen Zhang - z0216wen@sjtu.edu.cn Shixing Yang - yangshixing@sjtu.edu.cn Quan Shen - shenquan@sjtu.edu.cn Junfeng Liu - liujunfeng@sjtu.edu.cn Tongling Shan - shantongling@sjtu.edu.cn Fen Huang - huangfen@sjtu.edu.cn Huibo Ning - ninghuibo@sjtu.edu.cn Yanjun Kang - kangyanjun@sjtu.edu.cn Zhibiao Yang - zbyang@sjtu.edu.cn Li Cui - lcui@sjtu.edu.cn Jianguo Zhu - zhu_ja@sjtu.edu.cn Xiuguo Hua - hxg@sjtu.edu.cn Corresponding author Published 16 February 2009 Received I December 2008 Accepted 16 February 2009 Virology journal 2009 6 24 doi 10.1186 1743-422X-6-24 This article is available from http www.virologyj.cOm content 6 1 24 2009 Zhang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ In the present study a genotype 4 HEV strain was identified in the fecal specimen from a seven months old infant with no symptom of hepatitis in Shanghai Children s hospital. The full capsid protein gene ORF2 sequence of this strain was determined by RT-PCR method. Sequence analysis based on the full ORF2 sequence indicated that this HEV strain shared the highest sequence identity 97.6 with another human HEV strain isolated from a Japanese patient who was infected by genotype 4 HEV during traveling in Shanghai. .