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Báo cáo khoa học: "Protein intrinsic disorder and influenza virulence: the 1918 H1N1 and H5N1 viruses"

Tham khảo luận văn - đề án 'báo cáo khoa học: "protein intrinsic disorder and influenza virulence: the 1918 h1n1 and h5n1 viruses"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Virology Journal BioMed Central Open Access Protein intrinsic disorder and influenza virulence the 1918 H1N1 and H5N1 viruses Gerard Kian-Meng Goh 1 4 A Keith Dunker1 and Vladimir N Uversky 1 2 3 Address 1Center for Computational Biology and Bioinformatics Indiana University School of Medicine Indianapolis Indiana 46202 USA institute for Intrinsically Disordered Protein Research Indiana University School of Medicine Indianapolis Indiana 46202 USA institute for Biological Instrumentation Russian Academy of Sciences 142290 Pushchino Moscow Region Russia and institute of Molecular and Cell Biology Singapore 138673 Republic of Singapore Email Gerard Kian-Meng Goh - gerard@compbio.iupui.edu A Keith Dunker - kedunker@iupui.edu Vladimir N Uversky - vuversky@iupui.edu Corresponding authors Published 3 June 2009 Virology Journal 2009 6 69 doi 10.1186 1743-422X-6-69 Received 25 March 2009 Accepted 3 June 2009 This article is available from http www.virologyj.cOm content 6 1 69 2009 Goh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The 1918 H1N1 virus was a highly virulent strain that killed 20-50 million people. The cause of its virulence remains poorly understood. Methods Intrinsic disorder predictor PONDR VLXT was used to compare various influenza subtypes and strains. Three-dimensional models using data from X-ray crystallographic studies annotated with disorder prediction were used to characterize the proteins. Results The protein of interest is hemagglutin HA which is a surface glycoprotein that plays a vital role in viral entry. Distinct differences between HA proteins of the virulent and non-virulent strains are seen especially in the region near residues 68-79 of the HA2. This region represents the