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báo cáo hóa học:" Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients | Journal of Translational Medicine BioMed Central Research Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients Jun-ichi Kobayashi1 2 Toshihiko Torigoe 1 Yoshihiko Hirohashi1 Satomi Idenoue3 Akihiro Miyazaki2 Akira Yamaguchi2 Hiroyoshi Hiratsuka2 and Noriyuki Sato1 Address Department of Pathology Sapporo Medical University School of Medicine Sapporo Japan 2Department of Oral Surgery Sapporo Medical University School of Medicine Sapporo Japan and 3Department of Surgery Sapporo Medical University School of Medicine Sapporo Japan Email Jun-ichi Kobayashi - jkoba@sapmed.ac.jp ToshihikoTorigoe - torigoe@sapmed.ac.jp Yoshihiko Hirohashi - yhirohashi@yahoo.co.jp Satomi Idenoue - idenoue@sapmed.ac.jp Akihiro Miyazaki - amiyazak@sapmed.ac.jp Akira Yamaguchi - yamaguch@sapmed.ac.jp Hiroyoshi Hiratsuka - hiratuka@sapmed.ac.jp Noriyuki Sato - nsatou@sapmed.ac.jp Corresponding author Open Access Published 6 January 2009 Received 30 July 2008 Journal of Translational Medicine 2009 7 1 doi 10.1186 1479-5876-7-1 Accepted 6 January 2009 This article is available from http www.translational-medicine.com content 7 1 1 2009 Kobayashi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background We previously reported an HLA-A24-restricted cytotoxic T-cell epitope Survivin-2B80-88 derived from a splice variant of survivin survivin-2B. In this report we show a novel HLA-A24-restricted T-cell epitope Survivin-C58 derived from a wild type survivin and compared their immunogenicity in oral cancer patients. Methods By stimulating