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Báo cáo hóa học: " Translational Medicine - doing it backwards"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Translational Medicine - doing it backwards | Nussenblatt et al. Journal of Translational Medicine 2010 8 12 http www.translational-medicine.eom content 8 1 12 JOURNAL OF TRANSLATIONAL MEDICINE EDITORIAL Open Access Translational Medicine - doing it backwards Robert B Nussenblatt1 Francesco M Marincola2 Alan N Schechter3 Abstract In recent years the concept of translational medicine has been advanced in an attempt to catalyze the medical applications of basic biomedical research. However there has been little discussion about the readiness of scientists themselves to respond to what we believe is a required new approach to scientific discovery if this new concept is to bear fruit. The present paradigm of hypothesis-driven research poorly suits the needs of biomedical research unless efforts are spent in identifying clinically relevant hypotheses. The dominant funding system favors hypotheses born from model systems and not humans bypassing the Baconian principle of relevant observations and experimentation before hypotheses. Here we argue that that this attitude has born two unfortunate results lack of sufficient rigor in selecting hypotheses relevant to human disease and limitations of most clinical studies to certain outcome parameters rather than expanding knowledge of human pathophysiology an illogical approach to translational medicine. If we wish to remain true to our responsibility and duty of performing research relevant to human disease we must begin to think about fundamental new approaches. NIH is the nation s medical research agency - making important medical discoveries that improve health and save lives. NIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability 1 . Editorial A recent candidate for a post-doctoral fellowship position came to the laboratory for an interview