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Báo cáo hóa học: "Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for creutzfeldtjakob disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for creutzfeldtjakob disease | McKnight et al. Journal of Translational Medicine 2010 8 125 http www.translational-medicine.eom content 8 1 125 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Generalized cerebral atrophy seen on MRI in a naturally exposed animal model for creutzfeldt-jakob disease AIovÍtỉ I K ỉ k n Ỉ n H1 1 I A K l i n lzr tff 2t I Cl iffr in3 Rn I C1 l Thritnccitì4 Dcirr I I I Kor-Lar5 Alexia L McKiiigiit Lawience A Minkof Diane L Sutton Biuce V inumsen reiiy L Habeckei D xx rr x S V X I A Ct A V X zxx 6 í -X c m I l x 7 r nrtt rxtlrx A IA X r X V X I 18 I A r- E I r l x I t X t 9 IA z-x. ri I I A I zxxz -X zx Z l rzx r r I I 10 Raymond W Sweeney Gdiy Smith Constantin A Dasanu inomas t Icnim Doiu i Alexandiescu Joel M Stutmanm Abstract Background Magnetic resonance imaging has been used in the diagnosis of human piion diseases such as sCJD and vCJD but patients ate scanned only when clinical signs appeai often at the late stage of disease. This study attempts to answei the questions Could MRI detect piion diseases before clinical symptoms appeai and if so with what confidence Methods Scrapie the piion disease of sheep was chosen foi the study because sheep can fit into a human sized MRI scannei and there were no laige animal MRI scanneis at the time of this study and because the USDA had at the time of the study a sizeable sample of sciapie exposed sheep which we weie able to use foi this puipose. 111 genetically susceptible sheep that weie naturally exposed to sciapie weie used in this study. Results Oui MRI findings revealed no cleai consistent hypeiintense oi hypointense signal changes in the biain on eithei clinically affected oi asymptomatic positive animals on any sequence. Howevei in all 37 PiPSc positive sheep 28 asymptomatic and 9 symptomatic theie was a gieatei ventiicle to ceiebium aiea ratio on MRI compared to 74 PiPSc negative sheep fiom the sciapie exposed flock and 6 contiol sheep fiom certified sciapie fiee flocks as defined by immunohistochemistiy IHC .