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báo cáo hóa học: " Impact of schizophrenia and schizophrenia treatment-related adverse events on quality of life: direct utility elicitation"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí hóa học quốc tế đề tài : Impact of schizophrenia and schizophrenia treatment-related adverse events on quality of life: direct utility elicitation | Health and Quality of Life Outcomes BioMed Central Open Access Impact of schizophrenia and schizophrenia treatment-related adverse events on quality of life direct utility elicitation Andrew Briggs1 2 Diane Wild 1 Michael Lees1 Matthew Reaney1 Serdar Dursun3 David Parry4 and Jayanti Mukherjee4 Address 1Oxford Outcomes Ltd Oxford UK 2Section of Public Health and Health Policy University of Glasgow Glasgow UK 3Neuroscience and Psychiatry Unit The University of Manchester Manchester UK and 4Bristol-Myers Squibb Company Uxbridge UK Email Andrew Briggs - andrew.briggs@oxfordoutcomes.com Diane Wild - diane.wild@oxfordoutcomes.com Michael Lees - michael.lees@bayerhealthcare.com Matthew Reaney- matt.reaney@ahpresearch.com Serdar Dursun - Dursun@ualberta.ca David Parry - david.parry@bms.com Jayanti Mukherjee - jayanti.mukherjee@bms.com Corresponding author Published 28 November 2008 Received 30 June 2008 -r J.IA I A- - r Accepted 28 November 2008 Health and Quality of Life Outcomes 2008 6 105 doi 10.1186 1477-7525-6-105 This article is available from http www.hqlo.com content 6 1 105 2008 Briggs et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Objective To examine the impact of schizophrenia its treatment and treatment-related adverse events related to antipsychotics on quality of life from the perspective of schizophrenia patients and laypersons. Methods Health state descriptions for stable schizophrenia extra pyramidal symptoms EPS hyperprolactinemia diabetes weight gain and relapse were developed based on a review of the literature and expert opinion. The quality of life impact of each health state was elicited using a time trade-off instrument administered by interview to 49 stable schizophrenia patients and 75 .