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Wide Spectra of Quality Control Part 7

Tham khảo tài liệu 'wide spectra of quality control part 7', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 170 Wide Spectra of Quality Control Furthermore in sub-Saharan Africa the abuse of various drugs has increased considerably in the last decades. Many drugs used in treatment of tropical diseases have been implicated in various intentional and accidental poisoning. Adsorption and interaction of chlorapheneramine and chloroquine phosphate on pharmaceutical materials like magnesium trisilicate Activated charcoal magnesium carbonate and magnesium stearate was investigated by our research team. Freudlich Adsorption isotherm was adopted to evaluate adsorption capacity of each adsorbent on chloroquine phosphate. The freudlich parameter kf which is adsorption capacity obtained for the adsorbents are 0.053 0.145 0.131 and 0.173mg g for magnesium carbonate magnesium stearate magnesium trisilicate and activated charcoal respectively showed that these adsorbents have ability to adsorb or remove chloroquine phosphate molecules from solution at PH 5.0 Adediran et al 2006 The extent of adsorption of chloroquine phosphate by the adsorbents followed the sequence Activated charcoal magnesium trisilicate magnesium stearate magnesium carbonate. Differences in surface characteristics and chemical structure of adsorbent may be responsible for the trend observed above. Activated charcoal has the highest adsorption capacity which may be due to its organic nature and presence of phenolics and carboxyl moieties. Magnesium trisilicate Antacid adsorbed Chloroquine better than magnesium stearate because there is chemisorptions interaction between the negative charge of the adsorbent and positive charge of the drug molecule. The presence of small amount of oleate molecules in magnesium stearate enhances adsorption over magnesium carbonate. The findings are in agreement with the work of Mcginity and Lach 1976 Cooney 1977 and Guay et al 1984. Our investigation revealed that concurrent administration of these pharmaceutical adsorbents and chloroquine drug might interfere with chloroquine .