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Báo cáo hóa học: "Adaptive robot training for the treatment of incoordination in Multiple Sclerosis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Adaptive robot training for the treatment of incoordination in Multiple Sclerosis | Vergaro et al. Journal of NeuroEngineering and Rehabilitation 2010 7 37 http www.jneuroengrehab.eom content 7 1 37 IHlI JOURNAL OF NEUROENGINEERING NCR AND REHABILITATION RESEARCH Open Access Adaptive robot training for the treatment of incoordination in Multiple Sclerosis 1 t 1.2t 3 1.2 1.2 4 Elena Vergaro Valentina Squeri Giampaolo Brichetto Maura Casadio Pietro Morasso Claudio Solaro Vittorio Sanguineti1 2 Abstract Background Cerebellar symptoms are extremely disabling and are common in Multiple Sclerosis MS subjects. In this feasibility study we developed and tested a robot therapy protocol aimed at the rehabilitation of incoordination in MS subjects. Methods Eight subjects with clinically defined MS performed planar reaching movements while grasping the handle of a robotic manipulandum which generated forces that either reduced error-reducing ER or enhanced error-enhancing EE the curvature of their movements assessed at the beginning of each session. The protocol was designed to adapt to the individual subjects impairments as well as to improvements between sessions if any . Each subject went through a total of eight training sessions. To compare the effect of the two variants of the training protocol ER and EE we used a cross-over design consisting of two blocks of sessions four ER and four EE 2 sessions week separated by a 2-weeks rest period. The order of application of ER and EE exercises was randomized across subjects. The primary outcome measure was the modification of the Nine Hole Peg Test NHPT score. Other clinical scales and movement kinematics were taken as secondary outcomes. Results Most subjects revealed a preserved ability to adapt to the robot-generated forces. No significant differences were observed in EE and ER training. However over sessions subjects exhibited an average 24 decrease in their NHPT score. The other clinical scales showed small improvements for at least some of the subjects. After training movements became smoother and their .