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báo cáo hóa học: " Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition | Journal of Neuroinflammation BioMed Central Research Open Access Microglial inflammation in the parkinsonian substantia nigra relationship to alpha-synuclein deposition Emilie Croisier1 Linda B Moran1 David T Dexter2 Ronald KB Pearce1 and Manuel B Graeber 1 Address department of Neuropathology Division of Neuroscience and Mental Health Imperial College London and Hammersmith Hospitals Trust London UK and department of Cellular and Molecular Neuroscience Division of Neuroscience and Mental Health Imperial College London London UK Email Emilie Croisier - e.croisier@imperial.ac.uk Linda B Moran - l.moran@imperial.ac.uk David T Dexter - d.dexter@imperial.ac.uk Ronald KB Pearce - ronald.pearce@imperial.ac.uk Manuel B Graeber - m.graeber@imperial.ac.uk Corresponding author Published 03 June 2005 Received 26 April 2005 Journal of Neuroinflammation 2005 2 14 doi 10.1186 1742-2094-2-14 Accepted 03 June 2005 This article is available from http www.jneuroinflammation.cOm content 2 1 14 2005 Croisier et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The role of both microglial activation and alpha-synuclein deposition in Parkinson s disease remain unclear. We have tested the hypothesis that if microglia play a primary role in Parkinson s disease pathogenesis the microglial activated phenotype should be associated with histopathological and or clinical features of the disease. Methods We have examined microglial MHC class II expression a widely used marker of microglial activation the occurrence of CD68-positive phagocytes and alpha-synuclein immunoreactivity in post-mortem human substantia nigra affected by idiopathic Parkinson s disease PD . Using semi-quantitative severity ratings we have examined the .