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Báo cáo hóa học: " Genetic heterogeneity of L-Zagreb mumps virus vaccine strain"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Genetic heterogeneity of L-Zagreb mumps virus vaccine strain | Virology Journal BioMed Central Research Genetic heterogeneity of L-Zagreb mumps virus vaccine strain Tanja Kosutic-Gulija 1 Dubravko Forcic1 Maja Santak1 Ana Ramljak2 Sanja Mateljak-Lukacevic3 and Renata Mazuran1 Open Access Address Department for Research and Development Institute of Immunology Inc Rockefeller Street 10 Zagreb Croatia 2Department of Viral Vaccines Institute of Immunology Inc Rockefeller Street 10 Zagreb Croatia and 3Quality Control Department Institute of Immunology Inc Rockefeller Street 10 Zagreb Croatia Email Tanja Kosutic-Gulija - tgulija@imz.hr Dubravko Forcic - dforcic@imz.hr Maja Santak - msantak@imz.hr Ana Ramljak - Ana.Ramljak@pliva.hr Sanja Mateljak-Lukacevic - smateljak@imz.hr Renata Mazuran - rmazuran@imz.hr Corresponding author Published 10 July 2008 Received 24 April 2008 Virology Journal 2008 5 79 doi 10.1186 1743-422X-5-79 Accepted I0 July 2008 This article is available from http www.virologyj.cOm content 5 1 79 2008 Kosutic-Gulija et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background The most often used mumps vaccine strains Jeryl Lynn JL RIT4385 Urabe-AM9 L-Zagreb and L-3 differ in immunogenicity and reactogenicity. Previous analyses showed that JL Urabe-AM9 and L-3 are genetically heterogeneous. Results We identified the heterogeneity of L-Zagreb throughout the entire genome. Two major variants were defined variant A being identical to the consensus sequence of viral seeds and vaccine s and variant B which differs from variant A in three nucleotide positions. The difference between viral variants in L-Zagreb strain is insufficient for distinct viral strains to be defined. We demonstrated .