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Báo cáo hóa học: " Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection | Virology Journal BioMed Central Research Impairment of the CD8 T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus antigen or route of infection Joshua M DiNapoli Brian R Murphy Peter L Collins and Alexander Bukreyev Address Laboratory of Infectious Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health 50 South Drive Room 6505 Bethesda Maryland 20892 USA Email Joshua M DiNapoli - dinapolij@niaid.nih.gov Brian R Murphy - bmurphy@niaid.nih.gov Peter L Collins - pcollins@niaid.nih.gov Alexander Bukreyev - abukreyev@nih.gov Corresponding author Open Access Published 24 September 2008 Virology Journal 2008 5 105 doi l0.ll86 l743-422X-5-l05 Received 7 August 2008 Accepted 24 September 2008 This article is available from http www.virologyj.cOm content 5 l l05 2008 DiNapoli et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A subset of the virus-specific CD8 cytotoxic T lymphocytes CTL isolated from the lungs of mice infected with human respiratory syncytial virus RSV is impaired in the ability to secrete interferon Y IFNy a measure of functionality. It was suggested that the impairment specifically suppressed the host cellular immune response a finding that could help explain the ability of RSV to re-infect throughout life. Results To determine whether this effect is dependent on the virus the route of infection or the type of infection respiratory disseminated or localized dermal we compared the CTL responses in mice following intranasal IN infection with RSV or influenza virus or IN or intradermal ID infection with vaccinia virus expressing an RSV CTL antigen. The impairment was .