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Báo cáo hóa học: " Complete genome sequence of a highly divergent astrovirus isolated from a child with acute diarrhea"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Complete genome sequence of a highly divergent astrovirus isolated from a child with acute diarrhea | Virology Journal BioMed Central Open Access Complete genome sequence of a highly divergent astrovirus isolated from a child with acute diarrhea Stacy R Finkbeiner1 Carl D Kirkwood2 and David Wang 1 Address Departments of Molecular Microbiology and Pathology Immunology Washington University School of Medicine St. Louis MO USA and 2Enteric Virus Research Group Murdoch Childrens Research Institute Royal Children s Hospital Victoria Australia Email Stacy R Finkbeiner - srfinkbe@artsci.wustl.edu Carl D Kirkwood - carl.kirkwood@mcri.edu.au David Wang - davewang@wustl.edu Corresponding author Published 14 October 2008 Received 22 July 2008 Accepted 14 October 2008 Virology Journal 2008 5 117 doi 10.1186 1743-422X-5-117 This article is available from http www.virologyj.com content 5 1 1 17 2008 Finkbeiner et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Astroviruses infect a variety of mammals and birds and are causative agents of diarrhea in humans and other animal hosts. We have previously described the identification of several sequence fragments with limited sequence identity to known astroviruses in a stool specimen obtained from a child with acute diarrhea suggesting that a novel virus was present. Results In this study the complete genome of this novel virus isolate was sequenced and analyzed. The overall genome organization of this virus paralleled that of known astroviruses with 3 open reading frames identified. Phylogenetic analysis of the ORFs indicated that this virus is highly divergent from all previously described animal and human astroviruses. Molecular features that are highly conserved in human serotypes 1-8 such as a 3 NTR stem-loop structure and conserved nucleotide motifs present in the