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báo cáo hóa học:" Genetic lesions within the 3a gene of SARS-CoV"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Genetic lesions within the 3a gene of SARS-CoV | Virology Journal BioMed Central Short report Open Access Genetic lesions within the 3a gene of SARS-CoV Timothy HP Tan 1 Timothy Barkham2 Burtram C Fielding1 Chih-Fong Chou1 Shuo Shen1 Seng Gee Lim1 Wanjin Hong1 and Yee-Joo Tan1 Address 1Institute of Molecular and Cell Biology 61 Biopolis Drive 138673 Singapore and 2Tan Tock Seng Hospital 11 Jalan Tan Tock Seng 308433 Singapore Email Timothy HP Tan - ttan@imcb.a-star.edu.sg Timothy Barkham - Timothy_Barkham@ttsh.com.sg Burtram C Fielding - fieldingbc@imcb.a-star.edu.sg Chih-Fong Chou - mcbccf@imcb.a-star.edu.sg Shuo Shen - shenshuo@imcb.a-star.edu.sg Seng Gee Lim - sglim@imcb.a-star.edu.sg Wanjin Hong - mcbhwj@imcb.a-star.edu.sg Yee-Joo Tan - mcbtanyj@imcb.a-star.edu.sg Corresponding author Published 20 June 2005 Received 09 May 2005 Accepted 20 June 2005 Virology Journal 2005 2 51 doi l0.ll86 l 743-422X-2-51 This article is available from http www.virologyj.cOm content 2 1 51 2005 Tan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus SARS-CoV . We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts. Findings Introduction Numerous isolates of the severe acute respiratory syndrome coronavirus SARS-CoV have been completely sequenced 1-4 . In most cases only synonymous or non-synonymous substitutions have been reported within the major viral genes which include replicase 1a 1b gene products spike membrane nucleocapsid and envelope 1-4 . On the other hand large insertions or deletions have been found in the part of .