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báo cáo hóa học:"Barriers towards insulin therapy in type 2 diabetic patients: results of an observational longitudinal study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài :Barriers towards insulin therapy in type 2 diabetic patients: results of an observational longitudinal study | Hermanns et al. Health and Quality of Life Outcomes 2010 8 113 http www.hqlo.eom content 8 1 113 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Barriers towards insulin therapy in type 2 diabetic patients results of an observational longitudinal study 1 f 1 f 1 f 2f 1 f Norbert Hermanns Marina Mahr Bernd Kulzer Soren E Skovlund Thomas Haak 1 Abstract Background The course of barriers towards insulin therapy was analysed in three different groups of type 2 diabetic patients. This observational longitudinal study surveyed a three-month follow-up. Methods Participants in this study totalled 130 type 2 diabetic patients. The first subgroup was on insulin therapy at baseline group 1 n 57 age 55.6 8.7 yrs disease duration 12.7 7.2 yrs HbA1c 8.5 1.6 and remained on insulin at follow-up. Of an initial 73 insulin-naive patients 44 were switched to insulin therapy group 2 age 58.1 6.8 yrs disease duration 7.7 5.0 yrs HbA1c 9.1 1.7 and 29 patients remained on an oral regimen group 3 age 52.7 10.7 yrs disease duration 5.3 4.6 yrs HbA1c 8.3 1.4 . Barriers towards insulin therapy were measured using the Insulin Treatment Appraisal Scale ITAS . As generic instruments of health related quality of life patients completed also the Problem Areas of Diabetes Questionnaire PAID the WHO-5 Well-Being Scale WHO-5 the Centre for Epidemiologic Studies Depression Scale CES-D and the Trait Version of the State Trait Anxiety Inventory STAI at baseline and at three-month follow-up. Results At the three-month follow-up HbA1c had improved in all three groups 7.7 1.2 vs. 7.1 1.1 vs. 6.7 0.8 . The course of negative appraisal of insulin therapy was significantly different in the three groups p .003 the ITAS score increased in patients remained on oral antidiabetic drugs 51.2 12.2 to 53.6 12.3 whereas it decreased in patients switched to insulin therapy 49.2 9.8 to 46.2 9.9 or remained on insulin treatment 45.8 8.3 to 44.5 8.0 . Diabetes-related distress trait anxiety and well-being showed