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Pursuing Excellence in Healthcare_4

Tham khảo tài liệu 'pursuing excellence in healthcare_4', khoa học xã hội, kinh tế chính trị phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 92 Pursuing Excellence in Healthcare leaders of our academic medical centers and others involved in biomedical research to take a hard look at oversight of clinical trials their partnerships with the private sector their own ethical guidelines and the support and guidance they give their IRBs. Public confidence in clinical trials is essential to the continued advances in medicine we all hope to see in the next century. In addition the Department of Health and Human Services announced that it would take aggressive steps to mitigate conflicts of interest including the support of legislation to enable the FDA to levy civil monetary penalties for violations of informed consent and other research regulations. However these admonitions had little effect studies demonstrated that conflicts of interest persisted as evidenced by the following Of faculty investigators at the University of California San Francisco 7.6 had some personal financial ties with sponsors who supported their research 12 . A study of papers published by the New England Journal of Medicine and the Journal of the American Medical Association found a strong association between a positive outcome and the presence of a conflict of interest among the authors 13 . A review of studies published between January 1980 and October 2002 showed that one-fourth of the investigators had industry affiliations and two-thirds of the AMCs had equity in start-ups that sponsored the research 14 . Authors who had financial relationships with pharmaceutical companies were significantly more likely to reach supportive conclusions than authors without industry affiliations 14 . Only 47 of high-impact journals had policies in 2000 requiring disclosure of conflicts of interest 15 . Among journals that had conflict of interest policies few articles actually included conflict of interest disclosures 16 17 . A survey of 250 AMCs in 2000 found no established policies for dealing with physicians who failed to disclose conflicts of .