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Báo cáo hóa học: " Research Article Continuous Drug Infusion for Diabetes Therapy: A Closed-Loop Control System Design"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Research Article Continuous Drug Infusion for Diabetes Therapy: A Closed-Loop Control System Design | Hindawi Publishing Corporation EURASIP Journal on Wireless Communications and Networking Volume 2008 Article ID 495185 10 pages doi 10.1155 2008 495185 Research Article Continuous Drug Infusion for Diabetes Therapy A Closed-Loop Control System Design Jiming Chen 1 Kejie Cao 1 Youxian Sun 1 Yang Xiao 2 and Xu Kevin Su3 1 State Key Laboratory of Industrial Control Technology Institute of Industrial Process Control Zhejiang University Hangzhou 310027 China 2 Department of Computer Science The University of Alabama Tuscaloosa AL 35487 USA 3 Department of Computer Science University of Texas at San Antonio San Antonio TX78249 USA Correspondence should be addressed to Jiming Chen jmchen@ieee.org Received 15 July 2007 Revised 25 November 2007 Accepted 5 December 2007 Recommended by Hui Chen While a typical way for diabetes therapy is discrete insulin infusion based on long-time interval measurement in this paper we design a closed-loop control system for continuous drug infusion to improve the traditional discrete methods and make diabetes therapy automatic in practice. By exploring the accumulative function of drug to insulin a continuous injection model is proposed. Based on this model proportional-integral-derivative PID and fuzzy logic controllers are designed to tackle a control problem of the resulting highly nonlinear plant. Even with serious disturbance of glucose such as nutrition absorption at meal time the proposed scheme can perform well in simulation experiments. Copyright 2008 Jiming Chen et al. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. 1. INTRODUCTION Diabetes mellitus is a metabolic disorder in which insulin a kind of hormone which promotes the uptake of glucose into cells cannot properly perform its role. Diabetes Mel-litus affects more than 100 million individuals throughout the world and