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TARGETING NEW PATHWAYS AND CELL DEATH IN BREAST CANCER

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Carotenoids are hydrophobic compounds and thereby act as lipophilic antioxidants preventing polyunsaturated fatty acids from oxidative damages. In fact, carotenoids are incorporated into lipid membranes and thus could act as chain-breaking antioxidants by stopping free radical chain reactions (propagation of lipid peroxidation), scavenging lipid peroxyl radicals (LOO•), avoiding the abstraction of allylic hydrogens from neighboring lipids. Inactivation of lipoxygenase activity by carotenoids is also proposed as another mechanism of protection against oxidative stress. Although it is still controversial, it has been debated that vitamin E regenerates the radical form of cartenoids and vice versa (Palace et al., 1999; Mortensen et.

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