Đang chuẩn bị liên kết để tải về tài liệu:
CONTEMPORARY AND INNOVATIVE PRACTICE IN PALLIATIVE CARE

Không đóng trình duyệt đến khi xuất hiện nút TẢI XUỐNG Tải xuống

The most frequent chromosomal abnormality in CLL is deletion of 13q14, being monoallelic in 76% of cases, and biallelic in 24% [13, 14, 24]. This deletion, also detected in MBL [11] occurs at a much lower frequency in multiple myeloma, DLBCL, mature T-cell lymphomas, and in several solid tumors [25-29]. A minimal deleted region (MDR) has been defined in a large number of CLL cases with monoallelic 13q14 deletion. This region contains the long non-coding RNA deleted in leukemia (DLEU)-2, and the first exon of the DLEU1 gene [30, 31]. Two microRNAs (miR-15a and miR-16-1) were present within intron.