Đang chuẩn bị liên kết để tải về tài liệu:
BRAIN TUMORS CURRENT AND EMERGING THERAPEUTIC STRATEGIES

Không đóng trình duyệt đến khi xuất hiện nút TẢI XUỐNG Tải xuống

The major pathogenic mechanism of poststreptococcal glomerulonephritis (PSGN) is an in situ immune complex formation due to deposition of streptococcal nephritogenic antigens, such as nephritis-associated plasmin receptor (NAPlr) and Streptococcal pyrogenic exotoxin B (SPE B). Both are capable of activating the alternate pathway of the complement cascade and enhance the expression of adhesion molecules. SPE B also stimulates the production of chemotactic cytokines. NAPlr was isolated from group A streptococcus and was shown to bind plasmin(ogen). In the original report, 92 percent of Japanese patients with the acute PSGN had anti-NAPlr antibodies, and about 80% of renal biopsy samples showed deposits of NaPlr