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Sách: EMBRYOGENESIS

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Tubular organs are essential for organisms to establish transport systems for nutrients, liquids and gases. The development of tubes requires endocytosis of bound ligands, receptors and proteins at the plasma membrane (Bonifacino and Traub, 2003; Nelson, 2009). Clathrin coated vesicles (CCVs) organize major routes of cargo selective endocytosis in higher eukaryotic cells (Conner and Schmid, 2003). The formation of CCVs requires clathrin molecules. During CCV budding, clathrin molecules assemble to form a cage-like coat around the nascent vesicle membrane. Clathrin assembly is assisted by numerous adaptor proteins. After inward budding, CCV scission from the membrane is mediated by the large GTPase Dynamin. Released CCVs diffuse from the membrane.