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Particulate Air Pollution and Daily Mortality in Kathmandu Valley, Nepal: Associations and Distributed Lag

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Osteoporosis is a complex systemic skeletal disease that leads to an increased risk of fracture, usually of the vertebra, hip, wrist and humerus. The disorder is characterized by reduced bone mineral density (BMD), disrupted bone microarchitecture and alterations in the amount and variety of proteins in bone. During the last years a better understanding of the cellular mechanisms operating in bone remodeling, both for healthy and affected bones, was gained [26]. Bone turnover is a very complex process, depending on different genes and signaling pathways that coordinate osteogenesis, but also on other environmental factors. It is estimated that more than 60% of bone mass variance is determined by genetic factors [23]. Environmental factors account.

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