Đang chuẩn bị liên kết để tải về tài liệu:
Bacille Calmette-Guerin Vaccine-Induced Disease in hildren with HIV/AIDS

Không đóng trình duyệt đến khi xuất hiện nút TẢI XUỐNG Tải xuống

Bacille Calmette-Guerin Vaccine-Induced Disease in hildren with HIV/AIDS aims recognize clinical signs/symptoms suspicious for BCG disease in HIV-infected children; identify different forms of BCG-related complications in HIV-infected children; propose the appropriate work-ups and treatment for BCG. | Bacille Calmette-Guerin Vaccine-Induced Disease in Children with HIV/AIDS HAIVN Harvard Medical School AIDS Initiatives in Vietnam Learning Objectives By the end of this session, participants should be able to: Recognize clinical signs/symptoms suspicious for BCG disease in HIV-infected children Identify different forms of BCG-related complications in HIV-infected children Propose the appropriate work-ups and treatment for BCG BCG Vaccine: Overview (1) M. bovis is part of the Mycobacterium tuberculosis complex BCG (bacille Calmette-Guérin) is: a live attenuated strain of M. bovis, developed as a vaccine against TB disease inherently resistant to PZA and may be resistant to INH In TB-endemic countries including Vietnam, BCG is given at birth or shortly thereafter: Although BCG does not provide 100% protection against TB, it does reduce the risk of severe disease, namely meningeal and miliary TB, in children The rate of adverse effects due to the vaccine: Before HIV: 0.19-2 cases/million vaccinated infants EXPLAIN that M. bovis is part of the Mycobacterium tuberculosis complex included:M. tuberculosis, M. bovis, M. bovis BCG, M africanum, and M. microti M. bovis causes disease in cows, and occasionally in humans BCG Vaccine: Overview (2) Prompt treatment with both anti-mycobacterial and ARV therapies increases chance of survival Healthy infants and children usually only develop: injection site ulceration or lymphadenitis Because BCG is a live attenuated vaccine, it can cause disease in susceptible individuals: HIV infected infants are at a much greater risk of BCG related complications Disseminated disease: only occurs in severely immunocompromised individuals, and carries an extremely high mortality rate above 80% EXPLAIN that the rate of adverse effects is vary and depends on the vaccine strain, bacillary load, administration methods, and host immune characteristics. In general the vaccine is extremely safe in immunocompetent children. Source: . | Bacille Calmette-Guerin Vaccine-Induced Disease in Children with HIV/AIDS HAIVN Harvard Medical School AIDS Initiatives in Vietnam Learning Objectives By the end of this session, participants should be able to: Recognize clinical signs/symptoms suspicious for BCG disease in HIV-infected children Identify different forms of BCG-related complications in HIV-infected children Propose the appropriate work-ups and treatment for BCG BCG Vaccine: Overview (1) M. bovis is part of the Mycobacterium tuberculosis complex BCG (bacille Calmette-Guérin) is: a live attenuated strain of M. bovis, developed as a vaccine against TB disease inherently resistant to PZA and may be resistant to INH In TB-endemic countries including Vietnam, BCG is given at birth or shortly thereafter: Although BCG does not provide 100% protection against TB, it does reduce the risk of severe disease, namely meningeal and miliary TB, in children The rate of adverse effects due to the vaccine: Before HIV: 0.19-2 .