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Lecture Principles of biochemistry - Chapter 17 (part 1): Amino acid metabolism: Nitrogen assimilation and amino acid biosynthesis

Chapter 17 (part 1) - Amino acid metabolism: Nitrogen assimilation and amino acid biosynthesis. After completing this chapter, students will be able to: Know how different forms of nitrogen get to assimilatable form, know what types of organisms have this enzyme, know the reactions catalyzed by the enzymes below. Know structure of substrates and products, know co-enzymes and co-substrates involved,. | Chapter 17 (Part 1) Amino Acid Metabolism: Nitrogen Assimilation and Amino Acid Biosynthesis Nitrogen Cycle Nitrogenase Nitrate and Nitrite to Ammonia Ammonia Assimilation Glutamate Dehydrogenase Glutamine Synthetase (GS) Glutamine back to Glutamate Allosteric Modulation of GS Acitivity in Bacteria Regulation of Bacterial GS by Covalent Modification Glutamate serves as primary N- donor for AA synthesis through transamination reactions Transamination rxns involve Pyridoxol-phosphate and formation of Schiff Base Essential vs. Non-Essential AA’s Amino Acid Biosynthesis is a Diverse Process | Chapter 17 (Part 1) Amino Acid Metabolism: Nitrogen Assimilation and Amino Acid Biosynthesis Nitrogen Cycle Nitrogenase Nitrate and Nitrite to Ammonia Ammonia Assimilation Glutamate Dehydrogenase Glutamine Synthetase (GS) Glutamine back to Glutamate Allosteric Modulation of GS Acitivity in Bacteria Regulation of Bacterial GS by Covalent Modification Glutamate serves as primary N- donor for AA synthesis through transamination reactions Transamination rxns involve Pyridoxol-phosphate and formation of Schiff Base Essential vs. Non-Essential AA’s Amino Acid Biosynthesis is a Diverse . | Chapter 17 (Part 1) Amino Acid Metabolism: Nitrogen Assimilation and Amino Acid Biosynthesis Nitrogen Cycle Nitrogenase Nitrate and Nitrite to Ammonia Ammonia Assimilation Glutamate Dehydrogenase Glutamine Synthetase (GS) Glutamine back to Glutamate Allosteric Modulation of GS Acitivity in Bacteria Regulation of Bacterial GS by Covalent Modification Glutamate serves as primary N- donor for AA synthesis through transamination reactions Transamination rxns involve Pyridoxol-phosphate and formation of Schiff Base Essential vs. Non-Essential AA’s Amino Acid Biosynthesis is a Diverse Process | Chapter 17 (Part 1) Amino Acid Metabolism: Nitrogen Assimilation and Amino Acid Biosynthesis Nitrogen Cycle Nitrogenase Nitrate and Nitrite to Ammonia Ammonia Assimilation Glutamate Dehydrogenase Glutamine Synthetase (GS) Glutamine back to Glutamate Allosteric Modulation of GS Acitivity in Bacteria Regulation of Bacterial GS by Covalent Modification Glutamate serves as primary N- donor for AA synthesis through transamination reactions Transamination rxns involve Pyridoxol-phosphate and formation of Schiff Base Essential vs. Non-Essential AA’s Amino Acid Biosynthesis is a Diverse . | Chapter 17 (Part 1) Amino Acid Metabolism: Nitrogen Assimilation and Amino Acid Biosynthesis Nitrogen Cycle Nitrogenase Nitrate and Nitrite to Ammonia Ammonia Assimilation Glutamate Dehydrogenase Glutamine Synthetase (GS) Glutamine back to Glutamate Allosteric Modulation of GS Acitivity in Bacteria Regulation of Bacterial GS by Covalent Modification Glutamate serves as primary N- donor for AA synthesis through transamination reactions Transamination rxns involve Pyridoxol-phosphate and formation of Schiff Base Essential vs. Non-Essential AA’s Amino Acid Biosynthesis is a Diverse Process