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Comparision of the hemostatic efficacy from the combined bipolar probe coagulation with epinephrine injection and the bipolar proble coagulation alone in the treatment of peptic ulcer bleeding

Objectives: This study compared the combined bipolar probe coagulation with epinephrine injection during endoscopic process with the bipolar probe coagulation alone in the treatment for patients suffering from peptic ulcer bleeding. | Journal of military pharmaco-medicine No7-2016 COMPARISION OF THE HEMOSTATIC EFFICACY FROM THE COMBINED BIPOLAR PROBE COAGULATION WITH EPINEPHRINE INJECTION AND THE BIPOLAR PROBLE COAGULATION ALONE IN THE TREATMENT OF PEPTIC ULCER BLEEDING Le Quang Duc*; Tran Viet Tu**; Nguyen Quang Duat** SUMMARY Objectives: This study compared the combined bipolar probe coagulation with epinephrine injection during endoscopic process with the bipolar probe coagulation alone in the treatment for patients suffering from peptic ulcer bleeding. Subjects and methods: Patients who were endoscopically confirmed of peptic ulcer bleeding (active or visible vessel) during the period from January, 2010 through December, 2014, were prospectively randomized into two groups. The control group was treated by the bipolar probe coagulation alone (group 1); and the study group was treated by the combined bipolar probe coagulation with epinephrine injection during the endoscopic process (group 2). The primary outcomes, in terms of initial hemostasis, rate of recurrent bleeding within 72 hours, blood transfusion volume after the intervention, duration of hospital stay, and the potential risk of blood transfusion after the intervention were assessed. Results: The common rate of initial hemostasis was 97.5% (95.1% and 100% in group 1 and 2, respectively); the rate of recurrent bleeding in group 1: 5.2%, and group 2: 0% showing the remarkable success of hemostasis in group 2 (100%) compared to group 1 (90.2%) (p = 0.043); the blood transfusion after the intervention in group 1 and 2 were 792.9 ± 125.56 (p = 0.370) and 557.7 ± 41.76 mL, respectively; duration of hospital stay were 9.6 ± 3,01 and 8.9 ± 3.12 days (p = 0.167). As such, the combination method showed the reduction of the potential risk of blood transfusion after the intervention from 1.28 - 1.39 times in comparison with the bipolar probe coagulation alone method. Conclusion: The combined bipolar probe coagulation with epinephrine injection