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Evaluation of antibacterial effect by ozone therapy on burn injury

Accidental and war trauma, burns and all sorts of acute and chronic cutaneous infections can be proficiently treated with ozonated water. In current study, 24 burned rabbits were divided into 4 groups (6 rabbits in each group): topical treatment with saline; topical treatment with ozone; topical treatment with ozone and ozone autohemotherapy (OAHT); and topical treatment with silvirin. | Journal of military pharmaco-medicine 7-2013 EVALUATION OF ANTIBACTERIAL EFFECT BY OZONE THERAPY ON BURN INJURY Ho Anh Son*; Nguyen Linh Toan*; Vu Quoc Binh** SUMMARY Accidental and war trauma, burns and all sorts of acute and chronic cutaneous infections can be proficiently treated with ozonated water. In current study, 24 burned rabbits were divided into 4 groups (6 rabbits in each group): topical treatment with saline; topical treatment with ozone; topical treatment with ozone and ozone autohemotherapy (OAHT); and topical treatment with silvirin. The results showed that topical use of ozone in burn wounds present in animal model allow a rapid antibacterial effectiveness during the treatment periods. * Key words: Bacteria; Ozone autohemotherapy; Burn; Rabbit. INTRODUCTION Human skin is the barrier to prevent entering of bacteria to the body, when the skin is burned, these bacteria enter the wound and cause infection site. Bacteria can enter the burn wounds from healthy skin around, waste of patients, from the care people, from linens, from health care workers, and the atmosphere, drugs, the medical instruments Many reports have warned that burns hospital infections are a major cause of death in burn patients (accounting for 50 - 70%). The serious treated problem of drug-resistant bacteria present in the burn is also mentioned. Besides, the cost of using systematic and tropical antibiotics accounts for a large proportion of funding treatment. Therefore, we conducted this study using ozone as an antimicrobial substance with strong effect has been known for a long treated history, with a very low cost to assess their ability to antibacteria on the surface of burn wounds. SUBJECTS AND METHOD 1. Study subjects. Healthy Newzealand rabbits (from a farm in Hungyen province), medium weight 2 kg/each. Rabbits were breed in experimental conditions, individual clean cages during the study period and free access to food, vegetable. Total number of rabbits was 24, including