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Pharmaceutical crystallization in CouetteTaylor crystallizer: A case study of polymorphism of amino acid L-glutamic acid

The influence of intensity Taylor vortex flow in Couette-Taylor crystallizer on the crystallization of polymorphic amino acid Lglutamic acid was investigated in cooling crystallization. Here, the L-glutamic acid was chosen as the model crystal product, where it has two kinds of polymorphism including the unstable phase α-form and stable phase β-form crystal. | TAÏP CHÍ PHAÙT TRIEÅN KH&CN, TAÄP 19, SOÁ K6- 2016 Pharmaceutical crystallization in CouetteTaylor crystallizer: A case study of polymorphism of amino acid L-glutamic acid Khuu Chau Quang Dang Truong Giang Trinh Thi Thanh Huyen Nguyen Anh Tuan Institute of Chemical Technology, Vietnam Academy of Science and Technology (VAST) (Manuscript Received on Octorber 08th, 2016, Manuscript Revised Octorber 09th, 2016) ABSTRACT The influence of intensity Taylor vortex flow in Couette-Taylor crystallizer on the Couette-Taylor (CT) crystallizer was at least 2.0 times more effective as regards the selective β- crystallization of polymorphic amino acid Lglutamic acid was investigated in cooling form polymorphism and phase transformation time. The advantage of CT crystallizer over the crystallization. Here, the L-glutamic acid was chosen as the model crystal product, where it conventional ST crystallizer was explained in terms of the high shear stress and mass transfer has two kinds of polymorphism including the of unstable phase α-form and stable phase β-form crystal. In cooling crystallization, the α-form crystallizer. Here, the shear stress of Taylor vortex flow in CT crystallizer was at least 23.0 crystal transformed to the β-form crystal corresponding to the phase transformation of α- times higher than that of fluid motion in conventional ST crystallizer, whereas the mass form to β-form crystal. The present study found that the selective polymorphism of α-form and β- transfer of Taylor vortex flow in CT crystallizer was at least 1.2 times higher than that of fluid form crystal as well as the phase transformation motion in conventional ST crystallizer. As such, significantly depended on the intensity of turbulent Taylor vortex flow in Couette-Taylor the high turbulent shear stress of Taylor vortex flow was expected to promote the β-form crystallizer. Here, the selective β-form nucleation and phase transformation were nucleation via the .