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Lecture How to do Meta Analysis

This lecture includes these contents: How to do meta analysis, the popularity of meta analyses, four steps of meta analysis, identify your studies, how to search for literature,. Invite you to consult this lecture. | How to do Meta Analysis Arindam Basu Associate Director, Fogarty International Training Program Kolkata, India February, 2005 arin.basu@gmail.com phone: 919830153666 What is meta analysis? Quantitative approach for systematically combining results of previous research to arrive at conclusions about the body of research. What does it mean? Quantitative : numbers Systematic : methodical combining: putting together previous research: what's already done conclusions: new knowledge The popularity of meta analyses Number of Meta Analysis publications are steadily increasing since 1993. We graphed the counts of journal articles included “meta analysis” as “publication type” from Pubmed, from years 1993 through 2004 Four Steps of Meta Analysis Identify your studies Determine eligibility of studies Inclusion: which ones to keep Exclusion: which ones to throw out Abstract Data from the studies Analyze data in the studies statistically Identify your studies Be methodical: plan first List of popular databases to search Pubmed/Medline Embase Cochrane Review/Trials Register Other strategies you may adopt Hand search (go to the library.) Personal references, and emails web, eg. Google (http://scholar.google.com) How to Search for literature Formulate your question appropriately If you are searching pubmed Use Medical Subject Headings (MeSH) [1] Lookup word in text word, abstract, title [2] Combine [1] with [2] using boolean logic Set up proper filters For Others, use text word, abstract Huh?!, what is boolean logic?? Boolean Logic: AND this is AND zone, covering common area between two ellipses Boolean Logic OR this is boolean OR, covering the two ellipses Example: Research Issue Let's say we want to know whether streptokinase is protective for death from acute myocardial infarction. How should we set up a search strategy? We will search pubmed only The Search “streptokinase”[text word] OR “acute myocardial infarction”[text word] produces ALL articles that contain EITHER . | How to do Meta Analysis Arindam Basu Associate Director, Fogarty International Training Program Kolkata, India February, 2005 arin.basu@gmail.com phone: 919830153666 What is meta analysis? Quantitative approach for systematically combining results of previous research to arrive at conclusions about the body of research. What does it mean? Quantitative : numbers Systematic : methodical combining: putting together previous research: what's already done conclusions: new knowledge The popularity of meta analyses Number of Meta Analysis publications are steadily increasing since 1993. We graphed the counts of journal articles included “meta analysis” as “publication type” from Pubmed, from years 1993 through 2004 Four Steps of Meta Analysis Identify your studies Determine eligibility of studies Inclusion: which ones to keep Exclusion: which ones to throw out Abstract Data from the studies Analyze data in the studies statistically Identify your studies Be methodical: plan first List of .