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Hepatoprotective effects of phenolic glycosides from the methanol extract of physalis angulata

By various chromatographic separations, four phenolic glycosides, methyl salicylate 2-Otriglycoside (1), icariside E5 (2), quercetin 3-O-rutinoside (3), and isorhamnetin 3-O-rutinoside (4) were isolated from the methanol extract of the whole plant of Physalis angulata. Their structures were determined by 1D-, 2D-NMR spectroscopic analyses and by comparison with reported data. Compounds 3 exhibited significant hepatoprotective activity with an EC50 value of 17.08 µg/mL. This is the first report of 1-4 from Physalis angulata. | Journal of Science and Technology 55 (2) (2017) 161-167 DOI: 10.15625/0866-708X/55/2/8527 HEPATOPROTECTIVE EFFECTS OF PHENOLIC GLYCOSIDES FROM THE METHANOL EXTRACT OF PHYSALIS ANGULATA Hoang Le Tuan Anh1, *, Duong Thi Dung1, Do Thanh Tuan2, Trieu Quy Hung3, Pham Thi Hai Yen4, Tran Hong Quang1, Nguyen Xuan Nhiem1, Chau Van Minh1, Duong Thi Hai Yen1, Phan Van Kiem1, * 1 Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 2 3 4 Thai Binh Medical University, 373, Li Bon, Thai Binh Faculty of Natural Sciences, Hung Vuong University, Nguyen Tat Thanh, Viet Tri, Phu Tho, Thanh Hoa Sports and Physical Education College, 24 Hoang Van Thu, Ngoc Trao, Thanh Hoa * Email: phankiem@vast.vn Received: 15 July 2016; Accepted for publication: 6 January 2016 ABSTRACT By various chromatographic separations, four phenolic glycosides, methyl salicylate 2-Otriglycoside (1), icariside E5 (2), quercetin 3-O-rutinoside (3), and isorhamnetin 3-O-rutinoside (4) were isolated from the methanol extract of the whole plant of Physalis angulata. Their structures were determined by 1D-, 2D-NMR spectroscopic analyses and by comparison with reported data. Compounds 3 exhibited significant hepatoprotective activity with an EC50 value of 17.08 µg/mL. This is the first report of 1-4 from Physalis angulata. Keywords: Physalis angulata, phenolic glycoside, hepatoprotective effect. 1. INTRODUCTION Physalis is a genus of herbaceous plants in the Solanaceae family. The genus comprises approximately 120 species, mainly distributed worldwide in tropical and temperate regions. As reported by Vo Van Chi [1], in Vietnam the genus Physalis includes 4 species: P. angulata, P. alkekengi, P. peruviana and P. minima. Most species of the genus Physalis have been used for a long time in the ethnomedical folk traditions of Asian and American populations to treat different illnesses, such as malarial, asthma, hepatitis, dermatitis, liver disorders, and as an antimycobacterial, anticancer, .