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Evalution of anti-inflammatory and bronchodilator effects of Dinh Suyen P/H extract on experimental animals

The purpose of this study was to evaluate the anti-inflammatory and the bronchodilator effects of Dinh Suyen P/H extract in experimental animals. The anti-inflammatory activity of Dinh Suyen P/H extract was evaluated in an induced peritoneal inflammation model in rats and amiant-induced granuloma model in mice. | JOURNAL OF MEDICAL RESEARCH EVALUTION OF ANTI-INFLAMMATORY AND BRONCHODILATOR EFFECTS OF DINH SUYEN P/H EXTRACT ON EXPERIMENTAL ANIMALS Nguyen Thi Chau Loan1, Pham Thi Van Anh2, Pham Vu Khanh3, Nguyen Thi Thanh Loan2 1 Thai Binh University of Medicine and Pharmacy, 2 Department of Pharmacoloy, Hanoi Medical University, 3 Ministry of Health of Vietnam The purpose of this study was to evaluate the anti-inflammatory and the bronchodilator effects of Dinh Suyen P/H extract in experimental animals. The anti-inflammatory activity of Dinh Suyen P/H extract was evaluated in an induced peritoneal inflammation model in rats and amiant-induced granuloma model in mice. To evaluate the bronchodilator effect, the bronchospasmolytic activity in anesthetized guinea pig model was used. The present study demonstrated that Dinh Suyen P/H extract at dose 6.22 g/kg per day and 18.66 g/kg per day inhibited acute inflammatory activity in rats. The results obtained in the amiant-induced granuloma in mice did not show evidence of chronic anti-infammatory effect of Dinh Suyen P/H extract at dose 12.44 g/kg per day or 37.32 g/ kg per day. In addition, the findings of this study indicated that Dinh Suyen P/H extract at dose 8.29 g/kg per day inhibited the bronchocontriction in bronchospasmolytic activity in a guinea pig model. Keywords: Dinh Suyen P/H extract, anti-inflammatory, bronchodilator I. INTRODUCTION Asthma affects an estimated 300 million individuals worldwide. It is a serious global health problem affecting all age groups, with increasing prevalence in many developing countries, rising treatment costs and a rising burden for patients and the community [1; 2]. Inhaled corticosteroid is the most effective anti-inflammatory medications for persistent asthma. When a medium dose of inhaled corticosteroid alone fails to achieve good symptom control, the addition of a Corresponding author: Nguyen Thi Thanh Loan, Department of Pharmacoloy, Hanoi Medical University Email: .