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Preparation of cellulose coated hydrogels for controlled drug release

In an attempt to improve material properties used for oral administration, which is restricted by fast dissolution in the stomach, chitosan hydrogels were coated with cellulose dissolved in ionic liquid. Using insulin as a model compound, the properties of these cellulose-coated microparticles for the controlled release of drug were investigated. The results showed that the coated microparticles were more stable than those which were uncoated at low pH and suitable for oral delivery without requiring any harmful and sophisticated cross-linkage treatment. | Tạp chí Khoa học công nghệ và Thực phẩm 12 (1) (2017) 3-10 PREPARATION OF CELLULOSE COATED HYDROGELS FOR CONTROLLED DRUG RELEASE Thi Phuong Thuy Pham1*, Yeoung-Sang Yun2 1 Ho Chi Minh City University of Food Industry Chonbuk National University, Republic of Korea * Email: ptpthuybio@gmail.com 2 Received: 29 June 2017; Accepted for publication: 12 September 2017 ABSTRACT In an attempt to improve material properties used for oral administration, which is restricted by fast dissolution in the stomach, chitosan hydrogels were coated with cellulose dissolved in ionic liquid. Using insulin as a model compound, the properties of these cellulose-coated microparticles for the controlled release of drug were investigated. The results showed that the coated microparticles were more stable than those which were uncoated at low pH and suitable for oral delivery without requiring any harmful and sophisticated cross-linkage treatment. Keywords: Chitosan, hydrogels, cellulose, drug release. 1. INTRODUCTION The use of natural polymers in dosage form has received extensive attention, especially from the viewpoint of safety. Among these polymers, chitosan, the N-deacetylated product of the polysaccharide chitin, is gaining increasing importance in the pharmaceutical field owing to its good biocompatibility, non-toxicity and biodegradability [1, 2]. In the early 1980s, chitosan was proposed as a useful excipient for either sustaining the release of water-soluble drugs [3] or enhancing the bioavailability of poorly water-soluble compounds [4]. More recently, it has been shown that chitosan is muco-adhesive [5, 6] and enhances the penetration of macromolecules across the intestinal [7] and nasal [6] barriers. These properties have opened promising prospects for the use of this polymer in the oral and nasal administration of proteins and peptides. Furthermore, chitosan has been presented as a useful polymer for colon-specific drug delivery because of its specific biodegradation by .