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Study on anti-anxiety effect of Willughbeia cochinchinesis in scopolamine-administrered mice using open field test

The aim of this study is: To investigate effects of a new natural plant, Wullughbeia cochinchinensis (WC) to meliorate deficit in anxiety-like behaviors in mice by using the animal model. | Journal of military pharmaco-medicine no5-2018 STUDY ON ANTI-ANXIETY EFFECT OF WILLUGHBEIA COCHINCHINENSIS IN SCOPOLAMINC-ADMINISTERED MICE BY USING OPEN FIELD TEST Nguyen Tat Dinh*; Cao Tien Duc*; Le Van Quan** SUMMARY Objective: To investigate effects of Wullughbeia cochinchinensis to ameliorate disorders in anxiety-like behaviors of mice. Subjects and methods: In the present study, 50 Swiss mice were induced anxiety-like behaviors by scopolamine. Behaviors of mice treated with and without Wullughbeia cochinchinensis at doses of 100 mg/kg, 150 mg/kg and 200 mg/Kg and/or scopolamine were tested using the open field test. Results: Wullughbeia cochinchinensis at dose of 150 mg/kg and 200 mg/kg induced a significant increase in time spent, number of entries and travel distances in the center area of open field in animals with scopolamine-induced anxiety-like behaviors. Conclusion: Wullughbeia cochinchinensis 150 mg/kg and 200 mg/kg might ameliorate deficits in anxiety like symptoms in experimental animals. * Keywords: Anxiety, Mice; Willughbeia cochinchinensis . INTRODUCTION Anxiety is one of the common symptoms in mental disorders such as depression, phobia, etc. In a recent study, it has suggested that 33.7% of the population are affected by an anxiety disorder during their lifetime [1]. Furthermore, ratio of females with anxiety disorder is higher than this of male with this symptom [2]. In treatment, benzodiazepines have been suggested to be effective to anxiety disorders. However, these drugs might induce drug dependence when they are used a long time [3]. Thus, it is necessary to investigate new natural plants or drugs for treating anxiety disorders. It has suggested that anxiety-like disorders might relate to activities of achetylcholine. Thus, scopolamine, an antagonist to acetylcholinergic receptors, might be used to induce anxiety-like behaviors in experimental animals [4]. In the present study, we used this animal model to investigate effects of a .