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.Problem-based Approach to.Gastroenterology and Hepatology.Problem-based Approach.to Gastroenterology and.Hepatology.Edited byJohn N. Plevris MD, PhD, FRCPE, FEBGH.Consultant and Reader in Gastroenterology.Centre for Liver and Digestive Disorders.The Royal Infirmary of Edinburgh.Edinburgh, Scotland.UKColin W. Howden MD, FRCP (Glasg.), FACP, AGAF,.FACG.Professor of Medicine.Division of Gastroenterology and Hepatology,.Northwestern University Feinberg School of Medicine.Chicago.Illinois.USAA John Wiley & Sons, Ltd., Publication.This edition first published 2012 © 2012 by Blackwell Publishing Ltd.Blackwell Publishing was acquired by John Wiley & Sons in February 2007. Blackwell’s publishing.program has been merged with Wiley’s global Scientific, Technical and Medical business to form.Wiley-BlackwellRegistered office:John Wiley & Sons, Ltd, The Atrium, Southern Gate, Chichester, West Sussex,.PO19 8SQ, UKEditorial offices:9600 Garsington Road, Oxford, OX4 2DQ, UK.The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK.111 River Street, Hoboken, NJ 07030-5774, USAFor details of our global editorial offices, for customer services and for information about how.to apply for permission to reuse the copyright material in this book please see our website at.www.wiley.com/wiley-blackwell.The right of the author to be identified as the author of this work has been asserted in accordance.with the UK Copyright, Designs and Patents Act 1988All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or.transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or.otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the.prior permission of the publisherDesignations used by companies to distinguish their products are often claimed as trademarks. All.brand names and product names used in this book are trade names, service marks, trademarks or.registered trademarks of their respective owners. The publisher is not associated with any product or.vendor mentioned in this book. This publication is designed to provide accurate and authoritative.information in regard to the subject matter covered. It is sold on the understanding that the publisher.is not engaged in rendering professional services. If professional advice or other expert assistance is.required, the services of a competent professional should be soughtThe contents of this work are intended to further general scientific research, understanding, and.discussion only and are not intended and should not be relied upon as recommending or promoting a.specific method, diagnosis, or treatment by physicians for any particular patient. The publisher and.the author make no representations or warranties with respect to the accuracy or completeness of the.contents of this work and specifically disclaim all warranties, including without limitation any.implied warranties of fitness for a particular purpose. In view of ongoing research, equipment.modifications, changes in governmental regulations, and the constant flow of information relating to.the use of medicines, equipment, and devices, the reader is urged to review and evaluate the.information provided in the package insert or instructions for each medicine, equipment, or device.for, among other things, any changes in the instructions or indication of usage and for added.warnings and precautions. Readers should consult with a specialist where appropriate. The fact that.an organization or Website is referred to in this work as a citation and/or a potential source of.further information does not mean that the author or the publisher endorses the information the.organization or Website may provide or recommendations it may make. Further, readers should be.aware that Internet Websites listed in this work may have changed or disappeared between when this.work was written and when it is read. No warranty may be created or extended b