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Development of solidified self-microemulsifying drug delivery systems containing L-tetrahydropalmatine: Design of experiment approach and bioavailability comparison

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The study first aimed to apply a design of experiment (DoE) approach to investigate the influences of excipients on the properties of liquid self-microemulsifying drug delivery system (SMEDDS) and SMEDDS loaded in the pellet (pellet-SMEDDS) containing L-tetrahydropalmatine (l-THP). Another aim of the study was to compare the bioavailability of l-THP suspension, liquid SMEDDS and pellet-SMEDDS in the rabbit model. | Development of solidified self-microemulsifying drug delivery systems containing L-tetrahydropalmatine: Design of experiment approach and bioavailability comparison

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