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Application of Box-Behnken design with response surface methodology for optimizing synthesis conditions of Obidoxime chloride

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This combined process was successfully modeled and optimized using Box-Benhnken design with response surface methodology (RSM). The effects of the molar ratio, temperature and reaction time were investigated. Analysis of variance indicated that the prosed quadratic model successfully interpreted the experimental data with coefficients of determination of R2 = 0.9205. | Application of Box-Behnken design with response surface methodology for optimizing synthesis conditions of Obidoxime chloride

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