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A pilot study of aberrant CpG island hypermethylation of SPRED1 in acute myeloloid leukemia

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Epigenetic silencing of tumor suppressor genes plays important role in acute myeloid leukemia (AML). Recently, SPRED1, a negative regulator of the RAS MAPK pathway, is identified as a tumour suppressor downregulated in AML. | A pilot study of aberrant CpG island hypermethylation of SPRED1 in acute myeloloid leukemia

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