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Thrombospondin-1 gene deficiency worsens the neurological outcomes of traumatic brain injury in mice

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Thrombospondin-1 (TSP-1) is an extracellular matrix protein that plays multiple physiological and pathophysiological roles in the brain. Experimental reports suggest that TSP-1 may have an adverse role in neuronal function recovery under certain injury conditions. However, the roles of TSP-1 in traumatic brain injury (TBI) have not been elucidated. | Thrombospondin-1 gene deficiency worsens the neurological outcomes of traumatic brain injury in mice