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Role of biofilm production in bacteria isolated from device related and non-device related infection in a tertiary care hospital

The use of indwelling devices both temporary and permanent, in medical and surgical practice has led to the emergence of implant associated infections in the patients admitted in a Tertiary care hospital leading to partial or complete therapeutic failure. The study was conducted to detect and compare biofilm production in bacteria isolated from device related (DR) and non-device related (NDR) infections by Tissue Culture Method (TCP). A total of 200 bacterial isolates from various DR and NDR clinical samples of patients suffering from hospital acquired infections were subjected to biofilm detection and drug susceptibility testing. Of the 200 strains in the present study 121 bacterial strains were isolated from device related and 79 from non-device related clinical samples. Of the DR isolates, 86 (71.1%) were biofilm producers which included 10 (11.6%) strong, 37 (43%) moderate and 39 (45.4%) weak producers whereas of the NDR isolates 66 (83.5%) were biofilm producers including 18 (27.3%) strong, 21 (31.8%) moderate and, 27 (40.9%) weak producers respectively. Device related biofilm producing strains of Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa showed higher rate of drug resistance in comparison to their non-biofilm producing isolates. It is concluded that of bacteria isolates not only in device related infections but is also associated with multi drug resistance. Early detection of biofilm production will be of immense help in changing the modality of treatment with better patient outcome in device related infections. | Role of biofilm production in bacteria isolated from device related and non-device related infection in a tertiary care hospital