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Role of NS1 antigen in early detection of dengue during epidemics

Dengue has become a major international public health problem due to human morbidity and mortality it causes. Dengue NS1 antigen has been detected in the serum of DEN virus infected patients as early as one day of onset of symptoms. In this study the potential use of dengue NS1 antigen and in early dengue diagnosis has been analysed. The study group consists of all febrile patients with fever of duration less than 5 days attending the medical OPD for a period of one year from July 2013. The blood sample was subjected to an immunochromatographic test for NS1 antigen, IgM and IgG antibodies. This was followed by ELISA for NS1 antigen, IgM and IgG antibodies. Out of 176 samples tested, 57 (32%) were positive for NS1 antigen by immunochromatographic test. The 57 samples which were found to be positive by NS1 ELISA were also found to be positive by immunochromatographic test. NS1 antigen detection is a useful tool in the early diagnosis of dengue infection and deserves inclusion in the diagnostic algorithm for suspected dengue fever cases. The results of NS1 antigen immunochromatographic test are comparable to that of NS1 antigen ELISA. | Role of NS1 antigen in early detection of dengue during epidemics