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Evaluation of antifungal activity of curcumin against Aspergillus flavus

The present study was undertaken to study the antifungal effect of curcumin and other synthetic antifungal agents against Aspergillus species isolated from poultry feed. During this study poultry feeds collected from poultry farm of Odisha Veterinary College. Various concentrations of curcumin like 25mg/disc, 50mg/disc, 100mg/disc and 200mg/disc were prepared and were tested by disc diffusion method. In this method antifungal activity of various agents like ketoconazole, voriconazole, itraconazole, clotrimazole, Amphotericin B, miconazole, caspofungin, fluconazole were tested and its zone of inhibition was found to be approximately ≥ 18 mm, ≥ 15mm, ≥ 16mm, ≥ 18mm, ≥ 7 mm, ≥ 10mm, ≥ 18 mm and≥ 10mm respectively. It has been revealed that curcumin treated Aspergillus species showed lesser zone of inhibition than synthetic antifungals like ketoconazole, voriconazole, itraconazole, clotrimazole Amphotericin B, caspofungin but in comparison to fluconazole and miconazole curcumin shows larger zone of inhibition. The antifungal sensitivity pattern shows that curcumin (200 mg/disc) has got the highest potential of antifungal action against A. flavus and A. fumigatus in comparison to synthetic antifungals. | Evaluation of antifungal activity of curcumin against Aspergillus flavus