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Study on cytotoxicity and virus titration of chitosan nanoparticles encapsulated live PPR virus vaccine

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The cytotoxicity and virus titration of chitosan nanoparticles encapsulated live PPR virus vaccine (PPRV-CS-NPs) was analyzed in this study. Live attenuated PPR virus vaccine (AR-87) was encapsulated in chitosan nanoparticles using ionic gelation technique. The PPRV-CS-NPs were tested for cytotoxicity study in Vero cells with different concentrations (1-40 g).The cell viability was more than 80 per cent with all the concentration of the PPRV-CS-NPs tested. This indicates that the PPRV-CS-NPs are not toxic even in concentration higher than the required vaccine dose. The viability of PPRV (AR-87) in the PPRV-CS-NPs were tested by releasing the virus from nanoparticles by trypsin digestion. The virus titration was carried out in Vero cells and the titre was found to be 10 4.6TCID50/ml indicating that chitosan encapsulation was able to maintain virus infectivity. | Study on cytotoxicity and virus titration of chitosan nanoparticles encapsulated live PPR virus vaccine

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