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The inflammatory mediators and sepsis

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The occurrence, severity and mortality rates in human sepsis are increasing worldwide despite an increasing numerous clinical and experimental studies investigating sepsis. Sepsis is a severe clinical syndrome associated to the host response to infection. An auto-amplifying cytokine production: the cytokine storm is the main reason leading to the severity of infections. Cytokines are a large group of protein molecules that control the immune response during the inflammation in the body.