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Secretion of Fc-amidated peptide fusion proteins by Chinese hamster ovary cells

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The therapeutic use of α-amidated peptides (e.g. calcitonin, glucagon-like peptide) has increased dramatically, but there are major impediments to wider use of such peptides. Larger peptides are expensive to synthesize, and short plasma half-lives frequently limit the clinical circumstances in which the peptides would be useful. | Secretion of Fc-amidated peptide fusion proteins by Chinese hamster ovary cells

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