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Multicomponent synthesis of 4H-pyran derivatives using KOH loaded calcium oxide as catalyst in solvent free condition

A Convenient and green synthesis of 4H-pyran derivatives via one-pot multicomponent reaction of aromatic aldehydes, malononitrile and ethyl acetoacetate using KOH loaded CaO as a catalyst under solvent free condition is reported. The morphology of the catalyst has been characterized by XRD and TEM. | Multicomponent synthesis of 4H-pyran derivatives using KOH loaded calcium oxide as catalyst in solvent free condition Current Chemistry Letters 8 2019 125 136 Contents lists available at GrowingScience Current Chemistry Letters homepage www.GrowingScience.com Multicomponent synthesis of 4H-pyran derivatives using KOH loaded calcium oxide as catalyst in solvent free condition Archana Dhakara Rupendra Goyalb Archana Rajputa Manvendra Singh Kaurava Vinod S. Tomara and Dau D. Agarwala a SOS in Chemistry Jiwaji University Gwalior and 474011 India b SOS in Pharmaceutical Sciences Jiwaji University Gwalior and 474011 India CHRONICLE ABSTRACT Article history A Convenient and green synthesis of 4H-pyran derivatives via one-pot multicomponent Received November 12 2018 reaction of aromatic aldehydes malononitrile and ethyl acetoacetate using KOH loaded CaO Received in revised form as a catalyst under solvent free condition is reported. The morphology of the catalyst has been February 12 2019 characterized by XRD and TEM. This protocol have numerous advantages like lesser reaction Accepted April 6 2019 time environment friendly low cost easy to separate and provide higher yield. The Available online synthesized compounds have been characterized and confirmed by different spectroscopic April 6 2019 techniques like 1H NMR 13C NMR FT- IR and LC- MS. Keywords KOH loaded CaO Aldehyde Malononitrile Ethyl acetoacetate Knoevenagel condensation reaction 2019 by the authors licensee Growing Science Canada. 1. Introduction Multicomponent reactions MCRs are based on three or more reactants reacting in one step to form a single product which includes portion of all reactants. Heterocyclic compounds having functionalized nitrogen and oxygen play a significant role in medicinal chemistry and have been frequently utilized as scaffolds for the development of drugs. MCRs play an important role in organic chemistry which have come out as an effective means for delivering the molecular .