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5-[Substituted]-1, 3, 4-thiadiazol-2-amines: Synthesis, Spectral Characterization, and Evaluation of their DNA interactions

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The presence of heterocyclic moiety in diverse compounds, strongly indicative of the desired effect on physiological activity, and it reflects on efforts to find useful synthetic drugs. | 5- Substituted -1 3 4-thiadiazol-2-amines Synthesis Spectral Characterization and Evaluation of their DNA interactions Current Chemistry Letters 8 2019 157 168 Contents lists available at Growing Science Current Chemistry Letters Homepage www.GrowingScience.com 5- Substituted -1 3 4-thiadiazol-2-amines Synthesis Spectral Characterization and Evaluation of their DNA interactions N. Shivakumaraa b and P. Murali Krishnaa a Department of Chemistry Ramaiah Institute of Technology Bangalore 560054 India b Visvesvaraya Technological University Belagavi 590018 India CHRONICLE ABSTRACT Article history The presence of heterocyclic moiety in diverse compounds strongly indicative of the desired Received March 15 2019 effect on physiological activity and it reflects on efforts to find useful synthetic drugs. In this Received in revised form connection here reporting the synthesis and characterization of 5- substituted -1 3 4- April 18 2019 thiadiazol-2-amines 1-7 . All the prepared compounds were characterized by spectroscopic Accepted April 21 2019 methods viz. 1H-NMR 13C 1H -NMR FT-IR and LC-MS. The results of the DNA binding Available online interactions using absorption and fluorescence spectroscopy reveal that the compounds are avid April 21 2019 binders to DNA. A DNA cleavage study with pUC18 DNA using gel electrophoresis indicates Keywords the compounds are able to cleave DNA in presence of oxidant H2O2. 1 3 4-Thiadiazol-2-amines DNA interactions DNA cleavage studies 2019 by the authors licensee Growing Science Canada. 1. Introduction Recently interest in the synthesis and investigation of heterocyclic compounds forms major part of organic chemistry may be due to their vital role in the development of therapeutic drugs industrial catalysts etc. Literature survey1-6reveals that heterocyclic compounds containing sulphur and nitrogen have been under investigation due to their remarkable biological and industrial applications. Among thiadiazoles a five-membered .