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Microneedle pretreatment enhances the percutaneous permeation of hydrophilic compounds with high melting points

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Two commercially available microneedle rollers with a needle length of 200 μm and 300 μm were selected to examine the influence of microneedle pretreatment on the percutaneous permeation of four non-steroidal anti-inflammatory drugs (diclofenac, ibuprofen, ketoprofen, paracetamol) with different physicochemical drug characteristics in Franz-type diffusion cells. | Microneedle pretreatment enhances the percutaneous permeation of hydrophilic compounds with high melting points