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Alteration in the sensitivity to crizotinib by Na+ /H+ exchanger regulatory factor 1 is dependent to its subcellular localization in ALK-positive lung cancers

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Na+ /H+ exchanger regulatory factor 1 (NHERF1) is an important scaffold protein participates in the modulation of a variety of intracellular signal pathways. NHERF1 was able to enhance the effects of chemo-drugs in breast and cervical cancer cells. | Alteration in the sensitivity to crizotinib by Na H exchanger regulatory factor 1 is dependent to its subcellular localization in ALK-positive lung cancers

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