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Spatial UBE2N protein expression indicates genomic instability in colorectal cancers

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One major hallmark of colorectal cancers (CRC) is genomic instability with its contribution to tumor heterogeneity and therapy resistance. To facilitate the investigation of intra-sample phenotypes and the de novo identification of tumor sub-populations, imaging mass spectrometry (IMS) provides a powerful technique to elucidate the spatial distribution patterns of peptides and proteins in tissue sections. | Spatial UBE2N protein expression indicates genomic instability in colorectal cancers