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Tumor microenvironment conditions alter Akt and Na+ /H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: Implications for endothelial cell function in cancer

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Chronic angiogenesis is a hallmark of most tumors and takes place in a hostile tumor microenvironment (TME) characterized by hypoxia, low nutrient and glucose levels, elevated lactate and low pH. Despite this, most studies addressing angiogenic signaling use hypoxia as a proxy for tumor conditions. | Tumor microenvironment conditions alter Akt and Na H exchanger NHE1 expression in endothelial cells more than hypoxia alone Implications for endothelial cell function in cancer